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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2026-06-12 0:10 |
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Conference: Bucharest University Faculty of Physics 2026 Meeting
Section: Polymer Physics
Title:
Electrochemical sensor for serotonin detection in artificial plasma using a modified Graphene-Aniline microelectrode
Authors:
Ana-Maria Iordache1, Ana-Maria Florea1,2, Stefan Caramizoiu1,3, Bogdan-Ionut Bita1,2, Stefan-Marian Iordache1
*
Affiliation:
1) Optospintronics Department, National Institute of Research and Development for Optoelectronics - INOE 2000, 409 Atomistilor Street, Magurele, 077125, Romania;
2) Department of Electricity, Solid-State Physics and Biophysics, Faculty of Physics, University of Bucharest, 405 Atomistilor Street, P.O. Box MG-11, 077125 Magurele, Romania;
3) Department of Structure of Matter, Atmospheric and Earth Physics, Astrophysics,Faculty of Physics, University of Bucharest, 405 Atomistilor Street, P.O. Box MG-11, 077125 Magurele, Romania.
E-mail
ana.iordache@inoe.ro; stefan.iordache@inoe.ro
Keywords:
serotonin, electro-polymerization; sensors; Raman spectroscopy
Abstract:
Serotonin or 5-hydroxytryptamine (5-HT), a naturally occurring monoamine neurotransmitter, is a chemical that is involved in virtually all major organ systems, including the genitourinary, gastrointestinal, cardiovascular, and pulmonary systems, as well as in the central and enteric nervous systems. Depending on the characteristic of the receptor with which it interacts, 5-HT can modulate numerous human behaviour and physiological processes. In this study, we attempt to improve the detection methodology by combining electrochemical methods with Raman spectral analysis. Our methodology is based on the simultaneous electro-polymerization of graphene nanoplatelets and aniline directly onto the working electrode of a microsensor. The new modified sensor was used to evaluate the concentration of serotonin in synthetic plasma, and the QOD=100ng/mL and LOD=0.5 µg/ml were calculated.
Acknowledgement:
The authors were supported by the Core Program with the National Research Development and Innovation Plan 2022-2027, carried out with the support of MER, project no. PN 23 05.
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