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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2026-06-12 0:10 |
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Conference: Bucharest University Faculty of Physics 2026 Meeting
Section: Polymer Physics
Title:
Using key biochemical makers as early warning sensors of poor uterine healing: a systematic review
Authors:
Ionita Ducu1, Ana-Maria Iordache2, Stefan Caramizoiu2,4, Ana-Maria Florea2, Bogdan Bita2,3, Stefan-Marian Iordache2, Roxana Elena Bohiltea1
*
Affiliation:
1) “Carola Davila”University of Medicine and Pharmacy, Doctoral School of Medicine, Bucharest
2) Optospintronics Department, National Institute of Research and Development for Optoelectronics - INOE 2000, 409 Atomistilor, 077125, Magurele, Romania; stefan.iordache@inoe.ro (S.M.I.), ana.iordache@inoe.ro (A.M.I.)
3) Department of Electricity, Solid-State Physics and Biophysics, Faculty of Physics, University of Bucharest, 405 Atomistilor, 077125, Magurele, Romania;
4) Department of Structure of Matter, Atmospheric and Earth Physics, Astrophysics, Faculty of Physics, University of Bucharest, 405 Atomistilor Street, P.O. Box MG-11, 077125 Magurele, Romania.
E-mail
ana.iordache@inoe.ro; stefan.iordache@inoe.ro
Keywords:
biomedical markers; prevention medicine; sensors;
Abstract:
Poor healing of the uterus, particularly after surgical injuries like caesarean sections or within the context of intrauterine adhesions (IUA), is determined by a combination of persistent local inflammation and tissue ischemia (hypoxia). These factors disrupt the normal remodelling process, leading to thin, fibrotic scars or uterine dehiscence. Key markers of this impaired process include: markers of uterine ischemia and hypoxia, markers of chronic inflammation, molecular markers of poor scar formation. These markers can be used as early warning alert that can lead the medical team towards establishing a personalized course of medication focused on accelerating wound healing and reducing scar size, thus improving reproductive outcome.
Acknowledgement:
The authors were supported by the Core Program with the National Research Development and Innovation Plan 2022-2027, carried out with the support of MER, project no. PN 23 05.
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