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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2026-06-12 0:10 |
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Conference: Bucharest University Faculty of Physics 2026 Meeting
Section: Polymer Physics
Title:
Low-Q Cavity Biolasing for Single-Cell Optical Profiling
Authors:
Valentin BARNA(1), Dedy SEPTIADI(2), Luisa DE COLA(2), Dhruv SAXENA(3), Riccardo SAPIENZA(3) and Damiano GENOVESE(4)
Affiliation:
(1) Faculty of Physics - University of Bucharest, Bucharest, Romania
(2) Institut de Science et d’Ingénierie Supramoléculaires, Université de Strasbourg, Strasbourg, France
(3) The Blackett Laboratory, Imperial College London, London, UK
(4) Dipartimento di Chimica “Giacomo Ciamician”, Università di Bologna via Selmi 2, Bologna, Italy
E-mail
barnavalentin@yahoo.com
Keywords:
Biolasing, Light amplification, Low-quality-factor resonator
Abstract:
Researchers routinely use the spontaneous emission of fluorescent dyes to track cellular, organelle, and biomolecular activities with high spatio-temporal resolution. However, applying strong excitation fields and optical feedback allows stimulated emission to dominate, leading to laser action. Lasing offers a distinct advantage over standard fluorescence: it carries information about the local dye environment as well as the optical system generating the amplification—such as cavity geometries or scatterer densities—which fundamentally determines the spatial and spectral properties of the lasing modes. In this study, we generate biolasing by means of cells suspended in a low-quality-factor resonator made simply from a disposable poly(methyl methacrylate) (PMMA) cell-counting slide. Pronounced spectral narrowing and a sharp slope change in the input–output energy profile definitively confirm laser action. This biolasing manifests as an intrinsically dynamic signal, where large fluctuations in intensity and spectrum reflect the unique optical properties of individual cells passing through the pump beam.
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