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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2026-06-11 23:58 |
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Conference: Bucharest University Faculty of Physics 2026 Meeting
Section: Biophysics; Medical Physics
Title:
Thin films doped with antibiotic, obtained by MAPLE and deposited on electrofilated fibers, for applications in the treatment of infected wounds
Authors:
R.-M. GERU (1), A.T. MATEI (2), O. CRAMARIUC (2), A.I. VIȘAN (3), I. NEGUȚ (3), M.-E. BARBINTA-PATRASCU (1)
Affiliation:
(1) University of Bucharest, Faculty of Physics, Department of Electricity, Solid-State Physics and Biophysics, 405 Atomistilor Street, 077125, Magurele, Romania
(2) IT Center for Science and Technology, 25 No. Av. Radu Beller, 011702 Bucharest, Romania
(3) National Institute for Laser, Plasma and Radiation Physics, 409 Atomistilor Street, P.O. Box MG 36, 077125 Magurele, Romania
E-mail
geruryanna@gmail.com, negut.irina@inflpr.ro, marcela.barbinta@unibuc.ro
Keywords:
thin film, laser, antibacterial, inflammation
Abstract:
Chronically infected wounds represent a major challenge in regenerative medicine due to persistent inflammation and bacterial biofilm formation, which delays the normal healing process. In this context, the present work aims to develop composite thin films based on electrofilated fibers and antibiotic, for possible applications in the treatment of infected wounds. The films were obtained by the Matrix-Assisted Pulsed Laser Evaporation (MAPLE) technique. Morphological (SEM) and spectral (FTIR spectroscopy) characterization were performed. The release profile of the antibiotic in simulated body fluid was investigated by UV–Vis spectroscopy. The results obtained highlight the potential of these composite structures for controlled antibiotic release applications and advanced dressings for infected wounds.
References:
1) N. A. Shepelin, Z. P. Tehrani, N. Ohannessian, C. W. Schneider, D. Pergolesi, și T. Lippert, „A practical guide to pulsed laser deposition”, Chem. Soc. Rev., vol. 52, nr. 7, pp. 2294-2321, apr. 2023, doi: 10.1039/D2CS00938B.
2) S. Sharaf, A. El-Shafei, R. Refaie, A. Gibriel, și R. Abdel-Sattar, „Antibacterial and wound healing properties of cellulose acetate electrospun nanofibers loaded with bioactive glass nanoparticles; in-vivo study”, Cellulose, vol. 29, pp. 1-13, mai 2022, doi: 10.1007/s10570-022-04570-1.
Acknowledgement:
This research was funded by a grant from the Ministry of Education and Research, CCCDI—UEFISCDI, project number PN-IV-P7-7.1-PED-2024-0137, within PNCDI IV. This research was also funded by the Ministry of Education and Research under the Romanian National Nucleu Program LAPLAS VII—contract No. 30N/2023.
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