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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2026-06-11 23:58 |
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Conference: Bucharest University Faculty of Physics 2026 Meeting
Section: Solid State Physics and Materials Science
Title:
A Novel V-substituted Keggin polyoxotungstate: Synthesis, Characterization, and Ca2+-ATPase Inhibiting Potential
Authors:
Islem Meskini (1,2),*, Iulia Antohe (2), Gil Fraqueza (3,4), Frédéric Capet (5), Manuel Aureliano (6,7), Gabriel Socol (2) and Brahim Ayed (1),*
*
Affiliation:
1)Laboratory of Physico-chemistry of Materials LR01ES19, Faculty of Sciences, University of Monastir, Monastir, TUNISIA
2)National Institute for Lasers, Plasma and Radiation Physics (INFLPR), Atomistilor 409, 077125 Magurele, Ilfov, ROMANIA
3)The Superior Institute of Engineering (ISE), University of Algarve, 8005-139 Faro, PORTUGAL
4)The Centre for Biomedical Research (CBMR), Faculty of Sciences and Technology, University of Algarve, 8005-139 Faro, Portugal
5)University of Lille, CNRS, Centrale Lille, ENSCL, University of Artois, UMR 8181 - UCCS - Unit for Catalysis and Solid State Chemistry, F-59000 Lille, France.
6)Faculty of Sciences and Technology, University of Algarve, 8005-139 Faro, Portugal
7)Centre of Marine Sciences (CCMAR), University of Algarve, 8005-139 Faro, Portugal.
* Correspondig authors
E-mail
islemmes6@gmail.com; iulia.antohe@inflpr.ro
Keywords:
Polyoxometalates (POMs), P-type ATPases enzyme, V-substituted Lindqvist polyoxotungstate
Abstract:
Polyoxometalates (POMs) are a versatile class of discrete anionic metal–oxide clusters primarily composed of vanadium, molybdenum, and tungsten, characterized by remarkable structural tunability and diverse physicochemical properties. Owing to their pronounced biological activities, particularly their ability to modulate the activity of several enzymes, including P-type ATPases, POMs have emerged as promising candidates in medicinal and bioinorganic chemistry. In the present work, the inhibitory effect of a newly synthesized V-substituted polyoxotungstate on Ca²⁺-ATPase activity was investigated. The compound, formulated as (C6H15N)4(C6H16N)6(VW12O40)2·4H2O (POM-1), was successfully synthesized and comprehensively characterized by single-crystal X-ray diffraction, Fourier-transform infrared (FT-IR) spectroscopy, Raman spectroscopy, and solid-state emission spectroscopy. The inhibitory activity of POM-1 toward Ca²⁺-ATPase was evaluated spectrophotometrically at 22 °C using a coupled pyruvate kinase/lactate dehydrogenase assay. POM-1 exhibited significant inhibitory activity against Ca²⁺-ATPase, with an IC₅₀ value of 8.25 µM. Moreover, the inhibitory effect remained unchanged after 60 min of incubation, indicating the good stability of the polyoxometalate under the experimental conditions.
References:
[1] M. Aureliano, G. Fraqueza, M. Berrocal, J. J. Cordoba-Granados, N. I. Gumerova, A. Rompel, C. Gutierrez-Merino, A. M. Mata, Inhibition of SERCA and PMCA Ca2+-ATPase activities by polyoxotungstates. J. Inorg. Biochem. 236, (2022), 111952.
[2] L. Faleiro, A. Marques, J. Martins, L. Jordão, I. Nogueira, N. I. Gumerova, A. Rompel, M. Aureliano, The Preyssler-type polyoxotungstate exhibits anti-quorum sensing, antibiofilm, and antiviral activities. Biology 11, (2022), 994.
Acknowledgement:
The author would like to acknowledge the Laboratory of Physico-chemistry of Materials LR01ES19, Faculty of Sciences, University of Monastir, Monastir, Tunisia, for providing the academic foundation of this work. Thanks also extended to the University of Algarve, to the Erasmus+ International Credit Mobility project funded by the Portuguese National Agency, and to Portuguese national funds from FCT – Foundation for Science and Technology, through contracts UID/04326/2025, UID/PRR/04326/2025 and LA/P/0101/2020 (DOI:10.54499/LA/P/0101/2020). The authors also acknowledge the Romanian Ministry of Foreign Affairs and the Agence Universitaire de la Francophonie (AUF) for the Eugen Ionescu Research and Mobility Grant at the National Institute for Laser, Plasma and Radiation Physics (INFLPR). The authors further acknowledge the National Authority for Research and Innovation within the framework of the Nucleus Programme – LAPLAS VII (grant 30N/2023), as well as the grants of the Ministry of Research, Innovation and Digitalization, CNCS/CCCDI-UEFISCDI, project no. 19 PCE/2025 (PN-IV-P1-PCE-2023-1902), project no. 72/2024 (ERANET-M-3-Gas SensingMat-RT-1), and PoCIDIF no. 390008/27.11.2024.
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