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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2026-06-12 0:10 |
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Conference: Bucharest University Faculty of Physics 2026 Meeting
Section: Polymer Physics
Title:
Advances in Bioprinting of Polymeric Matrices for Tissue Engineering and Regenerative Medicine
Authors:
Bogdan BITA(1,2), Ana Maria IORDACHE(1), Ana Maria FLOREA (1,2), Stefan CARAMIZOIU (1,2), Irinela CHILIBON (1), Stefan Marian IORDACHE (1)
*
Affiliation:
1) Optospintronics Department, National Institute of Research and Development for Optoelectronics -INOE 2000, 409 Atomistilor, 077125, Magurele, Romania;
2) Department of Electricity, Solid-State Physics and Biophysics, Faculty of Physics, University of Bucharest, 11405 Atomistilor, 077125, Magurele, Romania;
E-mail
bogdan.bita@inoe.ro
Keywords:
· Bioprinting
· Polymeric matrix
· Tissue engineering
· Regenerative medicine
· Bioinks
· Biomaterials
· 3D bioprinting
· Extracellular matrix
· Scaffold fabrication
· Cell encapsulation
· Hydrogel
· Biocompatibility
· Synthetic p
Abstract:
Bioprinting of polymeric matrices represents a transformative approach in tissue engineering and regenerative medicine, enabling the fabrication of highly organised, biomimetic structures for biomedical applications[1]. Polymeric matrices used in bioprinting serve as scaffolds that support cell adhesion, proliferation, and differentiation while mimicking the extracellular matrix of native tissues[2]. Both natural polymers, such as alginate, gelatin, collagen, and chitosan, and synthetic polymers, including polycaprolactone (PCL) and polyethene glycol (PEG), are widely utilised due to their tunable mechanical, biological, and degradation properties. Advanced bioprinting techniques, such as extrusion-based, inkjet, and laser-assisted bioprinting, allow precise spatial deposition of bioinks containing living cells and biomaterials, resulting in complex three-dimensional constructs[3]. The selection of an appropriate polymeric matrix is critical for achieving structural integrity, biocompatibility, and controlled nutrient diffusion within printed tissues. Recent developments focus on improving printability, vascularisation, and mechanical performance to enhance the functionality of engineered tissues and organs. Polymeric matrices are currently being investigated for applications in skin, cartilage, bone, and cardiac tissue regeneration, as well as in drug screening and personalised medicine[4]. Despite significant progress, challenges remain regarding long-term stability, scalability, and clinical translation. Continued interdisciplinary research is expected to advance the development of functional bioprinted tissues and expand their therapeutic potential.
References:
1. Murphy, S.V.; Atala, A. 3D Bioprinting of Tissues and Organs. Nat. Biotechnol. 2014, 32, 773–785. https://doi.org/10.1038/nbt.2958
2. Groll, J.; Burdick, J.A.; Cho, D.W.; Derby, B.; Gelinsky, M.; Heilshorn, S.C.; Jüngst, T.; Malda, J.; Mironov, V.A.; Nakayama, K.; et al. A Definition of Bioinks and Their Distinction from Biomaterial Inks. Biofabrication 2018, 11, 013001. https://doi.org/10.1088/1758-5090/aaec52
3. Mandrycky, C.; Wang, Z.; Kim, K.; Kim, D.H. 3D Bioprinting for Engineering Complex Tissues. Biotechnol. Adv. 2016, 34, 422–434. https://doi.org/10.1016/j.biotechadv.2015.12.011
4. Matai, I.; Kaur, G.; Seyedsalehi, A.; McClinton, A.; Laurencin, C.T. Progress in 3D Bioprinting Technology for Tissue/Organ Regenerative Engineering. Biomaterials 2020, 226, 119536. https://doi.org/10.1016/j.biomaterials.2019.119536
Acknowledgement:
The author's work was supported by the CORE Program, carried out with the support of MCID, project no. PN 23 05.
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